PROKINETICIN RECEPTOR-1 SIGNALING INHIBITS DOSE- AND TIME-DEPENDENT ANTHRACYCLINE-INDUCED CARDIOVASCULAR TOXICITY VIA MYOCARDIAL AND VASCULAR PROTECTION

Objectives: This study investigated how different concentrations of doxorubicin (DOX) can affect the function of cardiac cells.This study also examined whether activation of prokineticin receptor (PKR)-1 by a nonpeptide agonist, IS20, prevents DOX-induced cardiovascular toxicity in mouse models.Background: High prevalence of heart failure during an

Santri merupakan istilah yang biasanya dipakai untuk menyebut siswa perempuan yang belajar atau menuntut ilmu di lingkungan pondok pesantren.Umumnya, santri masuk dalam kategori remaja dimana pada masa ini merupakan masa mengeksplorasi dan bereksperimen tentang segala hal, termasuk identitas seksual mereka.Penelitian ini dilatarbelakangi dengan ada

For decades, cardiovascular disease (CVD) has been the leading Tote Bag cause of death throughout most developed countries.Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD.CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles.Here, we present an in-d

Alkaline protease, pepsin and trypsin were used to hydrolyze the bones and meat, shell and skirt of Chinese soft-shelled turtle to prepare functional peptides, and their physical and chemical properties such as main conformational changes and particle size were analyzed.The potential bone mineral density-regulating activity of each enzymatic hydrol

Relevance.One of the main directions of development of mobile communication systems, radio engineering and telecommunication systems is the improvement of the structural form of the bearing supports, which will solve a number of practical tasks: to increase the coverage area, to ensure higher rates of data transmission speed and to ensure stable op